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A refusal to give an injection even one day early can prolong a period of distress and symptomatic decline

You want to differentiate which one of them is causing the issue

You can definitely opt for taking vitamin B12 supplements at night if that's what works best for you, although the natural energy-boosting abilities of vitamin B12 might be put to better use as you're starting the day

Mateos M-V, Blad J, Bringhen S, Ocio EM, Efebera Y, Pour L, Gay F, Sonneveld P, Gullbo J et al (2020) Melflufen: a peptidedrug conjugate for the treatment of multiple myeloma

Both are acceptable