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When a specific HMGB1 shRNA plasmid was constructed and transfected into BUC cells, RNAi technology successfully silenced HMGB1 expression, which significantly suppressed cell proliferation and induced apoptosis

Conventional treatments include NSAIDs, corticosteroid injections, and hyaluronic acid (HA) injections , but these often provide only temporary symptom relief without addressing the underlying pathology

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