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These reports often correspond with the adjustment period when gastrointestinal side effects are most pronounced

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(2) When the main peptide chain is coupled with the side chain with the carboxyl protected by the tert-butyl, compared with the process of directly reacting with the side chain without the tert-butyl protection, the reaction time of the invention is greatly shortened, the purity of the obtained intermediate compound 2 is higher, the residual quantity of the side products such as raw material Arg34GLP-1 (9-37) and the content of double modified impurities are far lower than the numerical values reported by the prior art, the higher the purity of the intermediate is, the fewer the impurities introduced into the final product are, and particularly the raw material Arg34GLP-1 (9-37) and the double modified impurities which are difficult to remove are reduced