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Contraindications Tolcapone is contraindicated in: Active liver disease Elevated baseline liver enzymes History of tolcapone-induced hepatotoxicity Severe hepatic impairment Hypersensitivity To view or add a comment, sign in Excellent graphic overview on pharmacological and clinical aspects of oral semaglutide in T2DM by Ney Carter Borges MD M.Sc

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2 The ideal anti-obesity drug Given the multifactorial pathogenesis of obesity [1], its treatment involves an integrated approach between different intervention modalities