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The Lancet Commission has identified numerous modifiable risk factors, including hypertension, diabetes, physical inactivity, and air pollution, that significantly contribute to the disease burden, in addition to aging (6)

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This leads to an increase in protein synthesis in muscle cells, promoting muscle hypertrophy and optimal muscle growth

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A Phase 2b clinical trial (Heffernan 2007, 300 obese patients) tested 1 mg/day subcutaneously over 12 weeks with a weight loss result of ~2.8 kg vs placebo

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