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Prior weight loss drugs were unpleasant (rimonabant), ineffective (Contrave), or dangerous (methamphetamine, fen-phen, 2,4-DNP)

The bark of the cascara sagrada shrub and juice from the leaves of aloe plants have been used for medicinal purposes

While the results were promising, the studies werent large enough to say definitively that berberine is an effective weight loss treatment, says Kathleen Jordan, MD, the chief medical officer at Midi Health in San Francisco

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IWQOL = impact of weight on quality life