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Subsequently, other publications reported beneficial effects of liraglutide in individuals with BAD (16,17)

A Cleveland Clinic analysis of nearly 8,000 patients found that discontinuing semaglutide and tirzepatide did not lead to significant immediate weight regain in clinical practice

Despite the great therapeutic potential of GLP-1R agonists, some challenges and shortcomings remain

The next critical step will be controlled clinical trials to confirm whether the observed associations translate into a reproducible, disease-modifying benefit

Marked improvements in lipid profile and blood pressure were also observed compared to placebo [81]