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Xiaflex is an injection that is used to break down collagen when the body forms too much in an area of the body

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The dosing regimen consisted of 5 mg/kg [34] given 12 h before ischemia induction, followed by twice-daily maintenance doses (every 12 h) until tissue collection, ensuring plasma concentrations above 200 ng/mL based on published pharmacokinetics (T/ = 10.5 h in rats).Control groups received equivalent volumes of vehicle (0.1% DMSO for intrathecal, corn oil for oral)

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