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Ultimately, this review proposes that PEM may arise from a complex interplay among mitochondrial dysfunction, immune activation, and neuroinflammation, which together form a self-perpetuating loop of energy exhaustion - inflammation amplification, potentially contributing to the chronic and multi-system nature of PEM symptoms

For that reason, technical sourcing decisions often include purity review, storage validation, and protocol matching to the underlying model rather than broad generalisation

PMID: 10918338

The animals were maintained under standard housing conditions at 22 2 C with 12/12-h light/dark cycles

These findings collectively demonstrate that FOXO4-DRI alleviates OGD-induced endothelial cell senescence and restores functional damage caused by OGD

N-acetylcysteine in COPD: Why, how, and when