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The common effects GI upset and the fishy odor are dose-related, benign, and reversible, and the controlled trials report good overall tolerability without serious adverse events as a feature

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Studies have shown that its concentrations are markedly elevated in both CSF and blood of PD patients, particularly in people living without dementia individuals, compared to healthy controls (222, 223)

Sep 2005;68(3):1244-1249

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These events as a coordinated hierarchy rather than as parallel abnormalities