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In a diet-induced steatohepatitis mouse model with fructose exposure, retatrutide was associated with changes in hepatic triglycerides, cholesterol levels, alanine aminotransferase, and inflammatory markers, providing a useful system for studying how tri-agonist signaling influences liver biology in experimentally induced steatotic states [7]

10.1038/nchembio.2079 123 ShouY.YangL.YangY.XuJ

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As a glucagon-like peptide-1 (GLP-1) receptor agonist, it works by mimicking the action of the GLP-1 hormone, which helps regulate blood sugar levels, reduce appetite, and promote a feeling of fullness

doi:10.1016/j.cmet.2010.04.001 5 Verdin E, Ott M