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The FLOW trial demonstrated cardiorenal benefit in chronic kidney disease (CKD) with T2D [22]

826 Downregulation of Panx1 significantly reduces ferroptosis and iron accumulation in renal cells induced by erastin, through inducing HO-1 expression and the mitogen-activated protein kinase (MAPK)/ERK pathway

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For instance, it promotes more mitochondrial content while inhibiting the creation of liver fat