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In murine models, FMT has shown therapeutic benefits by restoring Firmicutes species and attenuating systemic inflammation post-RT

Interestingly, Kv + channels are also important for remyelination ( + channel antagonist that blocks fast K + channels, to a mouse model of cuprizone-induced demyelination, resulted in impaired oligodendrocyte regeneration and remyelination ( Effect of Demyelination on Axonal Transport and Metabolism Axonal transport shuttles critical cell body-derived components back and forth between the soma and axon and across synapses in neurons (Millecamps and Julien, 2013)

doi: 10.1002/14651858.CD001301.pub2 224 ArhinSKZhaoYLuXChetryMLuJ

both antibiotic use and germ-free conditions suppress the expression of CYP7A1 and CYP27A1, key enzymes involved in BA production based on animal mechanistic studies (Chiang and Ferrell, 2019)

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