[17] Using a variety of tasks including the open field, elevated zero maze, y-maze, object location test and forced swim test, they found that CBD treatment following ischemic stroke resulted in reduced stroke-induced anxiety in the open field and elevated zero mazes, improved performance in the object location test and y-maze, and reduced depression-like symptoms in the forced swim test
But the mechanism isn't what most researchers initially assume
In the chronic administration paradigm, animals received two different treatment regimens: a cycle of 4 to 6 injections of cisplatin at 3 mg/kg given over the course of 3 weeks (once every 4 days), followed by a 5-day recovery or a cycle of 2 injections of cisplatin at 5 mg/kg given at a 4 day interval, followed by a 5-day recovery
Assimopoulos S, Hammill C, Fernandes DJ, Spencer Noakes TL, Zhou YQ, Nutter LMJ, et al
These results suggest that consistent, twice-weekly sessions sustained over multiple weeks are necessary before changes become noticeable
Loading phase: Some protocols include a short loading period, while others skip it and still reach similar muscle creatine levels over time