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Therefore, glycocalyx damage not only manifests as local pathologic changes in the organ but is also likely to be one of the common pathologic mechanisms for the progression of SAP to MODS

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Stress, a known exacerbating factor, can induce tinnitus-like behavior in animal models, linked to decreased expression of GABA A receptor 1 in the hippocampus, indicating a shift towards neuronal hyperexcitability

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