The Hostynek and Maibach group at UCSF measured exactly this in 2011: human skin permeation of GHK-Cu as a function of skin layer, with the result that the peptide accumulates in the upper stratum corneum but does not pass through to viable epidermis or dermis in any meaningful quantity 4
The net effect depends on concentration, timing, and cellular environment
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Pernicious anemia is one of those conditions
Weekly totals: GHK-Cu 12.5 mg, KPV 2.5 mg, BPC-157 2.5 mg, TB-500 2.5 mg
During these studies, they identified a protein that played a crucial role in maintaining the integrity of the gastrointestinal mucosa