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Based on these data, the FDA approved tesamorelin (marketed as EGRIFTA) for the reduction of excess abdominal fat in HIVassociated lipodystrophy, not as a general weightloss drug for the wider population. Tesamorelin Risks and Considerations Like all hormonemodulating therapies, tesamorelin carries potential risks, including fluid retention, joint pain, injectionsite reactions, and effects on glucose metabolism in susceptible patients

Mechanism: By suppressing perineural inflammation (TNF- suppression) and shifting microglia to a reparative phenotype, it creates an environment permissive for axonal sprouting

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Accordingly, an SNP of the forkhead box P3 (FoxP3) gene was linked to the more aggressive case of HT, a critical controlling player for the recovery of Tregs (Zaletel And Gaberscek 2011)

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