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Similarly, compounds from the spiro-oxindole dihydroquinazolinone series identified in the screening, e.g., 42 are weak inhibitors and besides that not stable in in vitro assays

Glutamatergic synaptic dysregulation in schizophrenia: therapeutic implications

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As organic acid testing to determine pyroglutamate is usually performed only at specialized pediatric hospitals with specialized biochemical genetics services, the diagnosis of this metabolic disorder in patients may frequently be missed