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Notably, the expression of enzyme-inactive caspase-8 (C362S) triggered necroptosis and pyroptosis, resulting in embryonic lethality and inflammatory tissue damage in mice [185]

No human safety data : The complete absence of human clinical trials means the safety profile, side effects, optimal dosing, and pharmacokinetics in humans are entirely unknown Animal-to-human translation is uncertain : Metabolic differences between mice and humans mean that the magnitude of effects (e.g., weight loss, grip strength improvement) may not translate

Cigna does not cover off-label Ozempic or Mounjaro for weight loss

Casan, J