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These results demonstrated that tirzepatide 10 and 15 mg had the lowest NNT, where an additional patient achieving the 5% weight reduction threshold would be observed if treating an additional 1.47 and 1.46 patients with tirzepatide 10 and 15 mg, respectively, rather than placebo

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The injection also reversed the feminization expression pattern of CYP2B9, CYP2D9, CYP4A12, CYP7B1, ELOVL3 (dominant expression genes in female mice) in the liver to that of wild-type male mice

Tissue ROS detection was performed as described 14