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SURMOUNT-1 enrolled 2,539 adults with obesity (BMI of 30 or higher) or overweight (BMI of 27 or higher) with at least one weight-related condition

One year after discontinuing treatment with OW sc 2.4 mg semaglutide in combination with lifestyle intervention, participants regained approximately two-thirds of their initial weight loss, along with similar reversals in cardiometabolic variables

10.1248/cpb.17.2625PubMed Abstract | CrossRef Full Text | Google Scholar 111 OthmanA.EhnertS.DropmannA.RuoM.NsslerA

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The difference is what happens between the moment you take it and the moment it reaches your bloodstream