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showed that the melanocortin-derived tripeptide KPV produced significant anti-inflammatory effects in DSS colitis and CD45RBhi transfer colitis models two of the most commonly used and accepted IBD research paradigms.1 Critically, the anti-inflammatory effect persisted even in animals with a nonfunctional MC1R receptor, confirming that KPV's action does not depend on melanocortin signaling

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Abstract In 2021 there were more than 106,000 drug overdose deaths in the United States alone (Spencer et al., Drug overdose deaths in the United States, 20012021

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