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SAFETY, TOLERABILITY, AND SPECIAL POPULATIONS The overall safety profile of GLP-1 RAs and multi-agonists is well-characterized from large clinical trials and real-world data

Mass spec at 817.41 Da is the verification target

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This provides approximately 4mcg/kg for a 160lb individual, falling within the effective clinical range

However, the lifestyle intervention guidelines, dating back to 20072008, do not address the need to precisely measure dose, frequency, and type of physical activity or diet and do not suggest ways (e.g., cardiopulmonary exercise testing) other than self-report to monitor intervention compliance or fidelity

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