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Future randomised controlled trials are needed to substantiate these associations, clarify the underlying mechanisms, and guide patient selection for optimal benefit

Moreover, no significant differences in plasma levels of TGF-, plasma cytokine or chemokine levels, or proportions of major B- and T-cell lymphocyte subsets, including numbers of regulatory T cells, were observed in healthy human subjects treated with placebo or sitagliptin 100 mg daily for 28 days (212)

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[PubMed: 17004848] [CrossRef] 44

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