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Current treatment includes a low fat, high carbohydrate diet and avoidance of fasting which dramatically improves prognosis allowing long term survival
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There was also a significant increase in urine of m+3 orotate, which is derived from pyruvate carboxylation to oxaloacetate, demonstrating another mechanism by which Cse / mice can waste carbon in the absence of CoA (Extended Data Fig
36 , 38 - 40 More supportive evidence in the context of viral hepatitis-triggered G6PD deficiency comes from recent studies analyzing hepatitis E-induced hemolytic anemia where significantly reduced glutathione in the red blood cells (RBCs) in G6PD-deficient state with an accumulation of oxidants due to hepatic dysfunction
Tomofuji Y, Kishikawa T, Maeda Y, et al
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