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These effects are also seen in patients with T2DM and in other insulin-resistant states such as obesity [135, 136] and may be mediated in part by restoration of vascular insulin sensitivity [137]
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Direct Cardiovascular Effects of GLP-1 Receptor Activation Beyond weight reduction, semaglutide activates GLP-1 receptors located directly on blood vessel walls and heart tissue, triggering vasodilationa relaxation and widening of blood vessels that reduces resistance to blood flow
Higher maintenance doses (such as 2.4 mg weekly for weight management) are associated with more persistent gastrointestinal symptoms compared to lower doses used for diabetes management
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