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Individual calorie needs should be calculated based on male/female needs, age, and activity level and adjusted throughout the weight loss journey to promote long-term weight management post GLP-1RA treatment (22)

Exogenous lactate can enter mitochondria as an oxidizable substrate for metabolic processes, exerting neuroprotective effects by improving energy supply, and its effects are independent of lactation modification

The deposition of A increases oxidative stress 33,34,35 , and the existence of an extra copy of superoxide dismutase 1 (SOD1) causes the overproduction of H 2 O 2

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Sudlow C, Gallacher J, Allen N, Beral V, Burton P, Danesh J, et al