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It is almost always about technique and preparation

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Andr J, Monreal D, Martinez de Tejada G, Olak C, Brezesinski G, Gomez SS, Goldmann T, Bartels R, Brandenburg K, Moriyon I: Rationale for the design of shortened derivatives of the NK-lysin-derived antimicrobial peptide NK-2 with improved activity against Gram-negative pathogens

The increased shear stress in the circulatory system can pose a threat to circulating tumor cells (CTCs), triggering apoptosis or necrosis [221, 222]