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The best letters connect your obesity to specific health outcomes, reference clinical guidelines supporting GLP-1 use, and explain why alternative treatments have been insufficient

For some, this program serves as a first step before bariatric surgery, allowing them to improve fitness, reduce liver size, or lower surgical risk

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Weber D, Davies MJ, Grune T

Br J Nutr 93(6):845851 Alvarez E, Martnez MD, Roncero I, Chowen JA, Garca-Cuartero B, Gispert JD et al (2005) The expression of GLP-1 receptor mRNA and protein allows the effect of GLP-1 on glucose metabolism in the human hypothalamus and brainstem

However, safety depends on dosage, timing, individual health status, and other medications you may be taking