As global DNA methylation refers to the average methylation status that occurs across the whole genome, MTHFR polymorphism could also destruct gene-specific methylation process which refers the methylation status of specific genes
Enhanced activation of mTOR leads to an increase in the phosphorylation of proteins downstream of mTORC1, such as S6 kinase (S6K) and eIF4E-binding proteins (4E-BPs), thereby promoting cap-dependent protein translation (66, 67)
Plant Physiol 159:4046 Wang PH, Lee CE, Lin YS, Lee MH, Chen PY, Chang HC, Chang IF (2019) The glutamate receptor-like protein GLR3.7 interacts with 14-3-3 and participates in salt stress response in Arabidopsis thaliana
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Although it has a powerful physiological function, more studies have focused on its pathological role, mainly because it is involved in the pathogenesis of several neurodegenerative diseases, such as Parkinsons disease (PD) and dementia of Lewy body (DLB) [7, 8]
