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The Cardiovascular Edge: Following the SOUL trial results in late 2025, Rybelsus is currently the only oral GLP-1 on the market with a proven cardiovascular (MACE) reduction label, making it a must-have for primary care physicians treating at-risk heart patients

On the primary endpoint, a standard clinical dementia rating, semaglutide was no better than placebo at slowing progression

Moderate alcohol consumption may be possible, but it can increase gastrointestinal side effects and should be approached cautiously

If your fundamentals are not in place, no peptide will compensate

Evidence-Based Combination Strategies The Rybelsus and Jardiance combination works well with other diabetes medications when additional glucose control is needed

That combination can make weight management more challenging and may show up as strong food cravings, low energy, and disrupted sleep