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Although many polymorphisms of MTP have been described, some of which have considerable impact on LDL cholesterol in both nondiabetic and diabetic subjects, it is difficult to know whether the results mainly stemmed from the effect in the liver rather than the intestine [75, 76]

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In nucleated cells, caspase-8, which is an initiator caspase of the extrinsic apoptotic pathway [144], has been identified as a molecular switch between apoptosis, necroptosis, and pyroptosis [145147]

This may include GLP-1 therapy, personalized dosing, and ongoing medical support

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