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doi:10.1016/j.freeradbiomed.2013.10.010 Cox AG, Pearson AG, Pullar JM, Jonsson TJ, Lowther WT, Winterbourn CC, Hampton MB (2009) Mitochondrial peroxiredoxin 3 is more resilient to hyperoxidation than cytoplasmic peroxiredoxins

While we used several markers (including SA--gal, lipofuscin, cyclin-dependent kinase inhibitors, SASP components and transcriptional senescence signatures) to characterize senescence in these models, we have to acknowledge the limitations of our study given the inherent heterogeneity of senescent cells

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Conclusions Peptide development is an important yet challenging endeavor, and many researchers have focused on inhibiting metalloproteinase-mediated cartilage degradation and promoting cartilage repair