glp 1 glp 2 dual agonist GLP-1/GIP receptor agonists mechanism of action Incretin-based therapies in MASLD/MASH: from

doi: 10.1038/s41374-018-0177-6

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Some individuals may experience mild digestive discomfort, including nausea, stomach upset, bloating, or diarrhea

Indeed, an important issue for the potential cognitive and mental health effects of GLP-1RAs, which our analysis cannot fully address, is whether these medications provide symptomatic relief only via their well-established cardiometabolic benefits, or by directly targeting physiopathological mechanisms behind cognitive and mental symptoms

Summary: This phase 3a, double-blind, randomized trial evaluated the combination therapy in adults with obesity and type 2 diabetes