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About 90% of the body serotonin is found in the gastrointestinal tract, where it regulates gut motility and communicates with the brainstem through the vagus nerve

For example, in particulate matter exposure-related models, GLS1-mediated enhancement of glutaminolysis, together with alterations in local Gln/-KG levels, can be accompanied by enhanced M1-like polarization, and inhibition of GLS1 can alleviate this pro-inflammatory polarization trend (60)

10.1046/j.1471-4159.1998.71010388.x 36

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