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With the evolving evidence and guidelines across the world, we should now choose second-line agents such as SGLT2i and GLP1-RAs with proven CV benefits in patients with high CV risk followed by agents with proven CV safety if additional glycemic control is required

Because melasma often involves inflammation and sun exposure, this mechanism can be helpful in targeted skincare routines

CJC-1295 No DAC is often discussed as Modified GRF 1-29 and is used in short-pulse research contexts

10.1042/CS20171107 59 LekawanvijitS.KompaA

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Furthermore, its short half-life of less than 3 h (Min et al., 2025) necessitates twice-daily injections to maintain efficacy, which can be a limiting factor for long-term patient adherence