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Methley AM, Campbell S, Chew-Graham C, McNally R, Cheraghi-Sohi S

To promote a 1- to 2-pound weight loss per week, a calorie deficit of 500 to 1000 calories is recommended

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As her urinary symptoms worsened and became increasingly refractory, she began using opioids obtained from nonmedical sources to manage bladder pain

The weight loss is not from fat burning or appetite suppression, but rather from the direct loss of glucose calories that would otherwise be stored or used by the body

doi: 10.1196/annals.1378.096