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Some manufacturers recommend taking supplements with food primarily to reduce potential stomach upset rather than to enhance absorption

Unlike the brand-name medications (Mounjaro and Zepbound), compounded versions are not covered by insurance

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Additionally, patients with inflammatory bowel disease, severe gastroesophageal reflux disease, or other significant gastrointestinal disorders should be monitored closely if treatment is initiated, as the gastrointestinal effects of semaglutide may worsen their underlying condition