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16 , 17 , 18 In addition, although no drug in this class has been observed to have a negative impact on cardiovascular (CV) outcomes, not all GLP1RAs have demonstrated CV benefits in CV outcomes trials

Furthermore, future studies should prioritize those parasitic helminths not studied so far and develop a small molecule database (i.e., helminth-specific) to allow researchers to dive deep into the treasure trove of helminth metabolites

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Metabolic endpoints (e.g., weight change, HOMA-IR, HbA1c) are most often supported by RCTs and therefore show relatively consistent and reproducible effects

Dose: 1 to 2 mg SC 2 to 3x weekly or topical 1 to 3% cream for skin applications