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Regulatory T (Treg) cells typically confer genetic resistance against organ-specific autoimmunity by actively suppressing the effector functions of self-antigen-reactive T cells, thereby inducing peripheral tolerance

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Importantly, elevated KYNA in the CNS may contribute to cognitive deficits in schizophrenia by antagonizing 7nAChRs and NMDARs, which are critical for synaptic plasticity, working memory, and cortical network coordination [76, 240,241,242]

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