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It puts nausea, vomiting, constipation, and abdominal pain at 20-50% of users, varying with titration speed and individual tolerance, and notes that rarer but more serious gastrointestinal problems also occur

Additionally, the trifluoromethyl triazole group is positioned within the extensive S 2 pocket, enabling further bonding interactions (89-92)

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Bernini et al

These include temporary skin redness, itch, or irritation after topical application, reported in a small percent of users, single-digit percentages in trials