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Cellular mechanisms of insulin resistance

In the resfile, different ranges of amino acid mutations were set for these two categories

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Moreover, we observed a pattern of gene expression consistent with the response to an iron overload, such as the upregulation of HMOX1 (encoding heme oxygenase 1) 69 , SLC40A1 (encoding ferroportin), FTH1 and FTL (encoding ferritin heavy and light chains, respectively) 70 , and metallothioneins 71 (Fig