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Most patients reach target dose (8-12mg for retatrutide) by week 16-20 and maintain that dose through week 48 with continued efficacy

[DOI] [PubMed] [Google Scholar] 14.Smeets K., Opdenakker K., Remans T., van Sanden S., van Belleghem F., Semane B., Horemans N., Guisez Y., Vangronsveld J., Cuypers A

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This decrease in production becomes especially noticeable during middle age