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Degraded semaglutide may not produce the same clean GLP-1 receptor activation, potentially causing irregular GI symptoms

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Folate, B6, and niacin also decline measurably when caloric intake drops below 1,500 calories daily

However, these studies individually are limited by small sample sizes, use of different comparison groups, and some lacked information on dose, which preclude a definitive assessment of the risk [see Data and Clinical Pharmacology (12.3)]

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