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The affinity of -tocopherol for TTP is significantly higher than that of other forms such as -tocopherol, meaning that -tocopherol is preferentially transported to tissues like the liver, heart, and brain

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May produce CNS concentrations with even lower systemic doses

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Constituents such as polyphenols, flavonoids, alkaloids, terpenes, saponins, and tannins have positively affected kidney health and various phytochemicals that exhibit anti-renal fibrosis effects through multiple signaling pathways [236, 237]