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Standard AOD-9604 Dosing Protocol Subcutaneous Injection Dosing: Beginner: 250 mcg per dose, once daily Intermediate: 300-400 mcg per dose, once daily or divided into two doses Advanced: 500 mcg per dose, once daily or 250 mcg twice daily Oral Administration Dosing (if using oral formulation): Standard: 1-2 mg per dose, once daily on empty stomach Higher protocols: Up to 5-10 mg daily, as studied in clinical trials Frequency: Once daily (morning preferred) or twice daily (morning and early afternoon) Timing: Best administered on an empty stomach, typically upon waking or before exercise Cycle Length: 12-16 weeks for initial assessment, with potential for longer protocols based on response Off Cycle: 4-8 weeks between cycles, though not strictly required based on current research Note: Start at the lower end of the dosing range to assess individual tolerance

doi: 10.1172/JCI.INSIGHT.161812 22 LongSAThorpeJDeBergHAGersukVEddyJAHarrisKMet al

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With Ipamorelin, you should look out for the following: Nausea Dryness in the mouth Redness at the injection site Fluctuations in appetite GENERAL CONSIDERATIONS Medical Consultation: Always consult with a healthcare provider or medical professional before starting any peptide-based treatment