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In addition, the classical metabolic drug metformin increases oocyte maturation rate and early embryonic developmental potential in aged mice cultured in an in vitro maturation system through a mechanism involving SIRT3-mediated deacetylation of SOD2, which mitigates mitochondrial damage [362]

10.1016/j.cbpb.2021.110706 29 HofsteeP.BarthoL.McKeatingD.HollandO.VanderlelieJ.CuffeJ.et al (2017)

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The effects of SGLT2 inhibitors on lipid metabolism

Many patients experience gastrointestinal symptoms as their body adjusts to the medication