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All participants had overweight or obesity (BMI 27 kg/m) and pre-existing cardiovascular disease (CVD) but notably no diabetes

The approval positions the pill as a potential alternative to injectable GLP-1 therapies and is expected to become available in the US in early January 2026

Women who are pregnant, planning pregnancy, or breastfeeding should consult their physician before using this medication

Waist circumference typically decreases by 1-2 cm

For instance, weight loss is not immediate, especially at lower doses during the titration period

328,329 Thus, inhibition of DNL and related pathway may effectively alleviate MAFLD and IR