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Circ Res 115(12):10171025 Beliaev A, Ferreira H, Learmonth DA, Soares-da-Silva P (2009) Dopamine -monooxygenase: mechanism, substrates and inhibitors

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Ongoing maintenance cycles (2 to 3 times per year) help sustain the improvements and counter the natural age-related decline in collagen production

Initially we may have gut issues (reflux, bloating, cramping, diarrhoea), and if histamine breaks through gut to the bloodstream we may get hives, migraines, heart palpitations, anxiety, insomnia, and vertigo