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A likely contributor to this iron accumulation is the reduction in ferroportin expression that inhibits iron export from DSCs

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Giralt, J

Furthermore, metformin diminishes the presence of Bacteroides fragilis , a bacterium that suppresses bile salt hydrolase activity, leading to a rise in secondary bile acids like GUDCA

Mechanistically, loss of Ssu72 inhibits PPAR-mediated adipogenesis and lipid storage by hyperphosphorylation of GSK3, resulting in suppression of WAT expansion

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